Brugada Syndrome

**Definition:** An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.

**Tree numbers:** - C14.280.067.322 - C14.280.123.250 - C16.320.100

**Synonyms:** - Right Bundle Branch Block, ST Segment Elevation, and Sudden Death Syndrome - Sudden Unexplained Nocturnal Death Syndrome (SUNDS) - Sudden Unexplained Nocturnal Death Syndrome - Sudden Unexplained Death Syndrome