Leukemia, Large Granular Lymphocytic

**Definition:** A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.

**Tree numbers:** - C04.557.337.428.580.049 - C15.378.508.428.580.049 - C15.604.515.560.575.049 - C20.683.515.528.582.049

**Synonyms:** - Aggressive NK Cell Leukemia - Leukemia, Lymphocytic, Large Granular - Lymphoproliferative Disease of Granular Lymphocytes - LGL Leukemia - Lymphoproliferative Disease of Large Granular Lymphocytes - Leukemia, LGL - Aggressive Natural Killer Cell Leukemia - Large Granular Lymphocyte Leukemia