Marchiafava-Bignami Disease

**Definition:** A neurodegenerative condition that is characterized by demyelination or necrosis of the CORPUS CALLOSUM. Symptoms include DEPRESSION; PARANOIA; DEMENTIA; SEIZURES; and ATAXIA which can progress to COMA and death in a few months. Marchiafava-Bignami syndrome is seen often in alcoholics but has been found in non-alcoholics as well.

**Tree numbers:** - C10.228.140.163.510 - C10.314.475

**Synonyms:** - Marchiafava-Bignami Syndrome