rho-Associated Kinases

**Definition:** A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.

**Tree numbers:** - D08.811.913.696.620.682.700.814 - D12.776.476.563.814

**Synonyms:** - rho-Kinase - rho-Associated Kinase - ROK Kinase - rho-Associated Coiled-Coil Kinase - ROCK Protein Kinases