Protein Tyrosine Phosphatase, Non-Receptor Type 12

**Definition:** A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of a N-terminal catalytic domain and a large C-terminal domain that is enriched in PROLINE, GLUTAMIC ACID, SERINE, and THREONINE residues (PEST sequences). The phosphatase subtype is ubiquitously expressed and implicated in the regulation of a variety of biological processes such as CELL MOVEMENT; CYTOKINESIS; focal adhesion disassembly; and LYMPHOCYTE ACTIVATION.

**Tree numbers:** - D08.811.277.352.650.775.300.850 - D12.776.476.564.300.850

**Synonyms:** - PEST-Enriched Phosphatase - PTP-PEST - PEP Protein Tyrosine Phosphatase - PEP PTPase