Protein Tyrosine Phosphatase, Non-Receptor Type 22

**Definition:** A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.

**Tree numbers:** - D08.811.277.352.650.775.300.930 - D12.776.476.564.300.930

**Synonyms:** - PTPN-22 Protein - PTPase Lyp - Protein-Tyrosine Phosphatase Lyp - Lymphoid Phosphatase - Tyrosine Protein Phosphatase, Non-Receptor Type 22