Cyclic Nucleotide Phosphodiesterases, Type 1

**Definition:** A CALCIUM and CALMODULIN-dependent cyclic nucleotide phosphodiesterase subfamily. The three members of this family are referred to as type 1A, type 1B, and type 1C and are each product of a distinct gene. In addition, multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing. Although the type 1 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), some members of this class have additional specificity for CYCLIC GMP.

**Tree numbers:** - D08.811.277.352.640.150.100 - D08.811.277.352.640.155.100 - D12.776.476.008.100 - D12.776.476.009.100

**Synonyms:** - Ca(2+)-CaM-Stimulated PDE - Calcium-Calmodulin-Stimulated Cyclic AMP Phosphodiesterase - Cyclic Nucleotide Phosphodiesterases, Type I - PDE1 Phosphodiesterases - Cyclic Nucleotide Phosphodiesterase PDE1 Family - Ca++ Calmodulin Dependent Cyclic AMP Phosphodiesterase - Calmodulin Phosphodiesterase - Calmodulin-Dependent Phosphodiesterase - Ca-CaM-Phosphodiesterase - Calcium-Calmodulin-Dependent Phosphodiesterase - Calmodulin-Dependent cGMP Phosphodiesterase