Cyclic Nucleotide Phosphodiesterases, Type 4

**Definition:** A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.

**Tree numbers:** - D08.811.277.352.640.150.400 - D12.776.476.008.400

**Synonyms:** - Phosphodiesterase IV - Type 4 Cyclic Nucleotide Phosphodiesterase - Phosphodiesterase-4 - Cyclic Nucleotide Phosphodiesterase PDE4 Family - PDE4 Phosphodiesterases - Phosphodiesterase 4