Ribosome Inactivating Proteins

**Definition:** N-Glycosidases that remove adenines from RIBOSOMAL RNA, depurinating the conserved alpha-sarcin loop of 28S RIBOSOMAL RNA. They often consist of a toxic A subunit and a binding lectin B subunit. They may be considered as PROTEIN SYNTHESIS INHIBITORS. They are found in many PLANTS and have cytotoxic and antiviral activity.

**Tree numbers:** - D08.811.277.450.430.700 - D12.776.765.710

**Synonyms:** - Polynucleotide Adenosine Glycosidase - RIP (Ribosome Inactivating Proteins) - RNA Glycosylase - RNA N-Glycosidase - rRNA N-Glycosylases - RIP Ribosome Inactivating Proteins