G-Quadruplexes

**Definition:** Higher-order DNA and RNA structures formed from guanine-rich sequences. They are formed around a core of at least 2 stacked tetrads of hydrogen-bonded GUANINE bases. They can be formed from one two or four separate strands of DNA (or RNA) and can display a wide variety of topologies, which are a consequence of various combinations of strand direction, length, and sequence. (From Nucleic Acids Res. 2006;34(19):5402-15)

**Tree numbers:** - G02.111.570.820.486.550 - G05.360.580.550

**Synonyms:** - Guanine-Quadruplexes