Growth Differentiation Factor 1

**Definition:** A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS.

**Tree numbers:** - D12.644.276.954.300.100 - D12.644.276.954.550.100 - D12.776.467.942.300.100 - D12.776.467.942.550.100 - D23.529.942.300.100 - D23.529.942.550.100

**Synonyms:** - GDF-1