Insulin Receptor Substrate Proteins

**Definition:** A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.

**Tree numbers:** - D12.644.360.024.301 - D12.776.157.057.045 - D12.776.476.024.382

**Synonyms:** - IRS Signaling Adaptor Proteins