CCN Intercellular Signaling Proteins

**Definition:** A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN.

**Tree numbers:** - D12.644.276.200 - D12.776.467.200 - D12.776.860.300.200 - D23.529.237

**Synonyms:** - CYR61 CTGF NOV Matricellular Proteins - CCN Family Proteins - Matricellular CCN Proteins