Primary Myelofibrosis

**Definition:** A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.

**Tree numbers:** - C15.378.190.636.765

**Synonyms:** - Agnogenic Myeloid Metaplasia - Bone Marrow Fibrosis - Fibrosis, Bone Marrow - Myelofibrosis - Myelofibrosis With Myeloid Metaplasia - Myeloid Metaplasia - Myelosclerosis - Myelosis, Nonleukemic - Chronic Idiopathic Myelofibrosis - Idiopathic Myelofibrosis