SOX Transcription Factors

**Definition:** A large family of structurally-related transcription factors that were originally discovered based upon their close sequence homology to an HMG-box domain found in SEX-DETERMINING REGION Y PROTEIN. Many SOX transcription factors play important roles in regulating CELL DIFFERENTIATION. The numerous members of this family are organized in several subgroups according to structural identities found within the proteins.

**Tree numbers:** - D12.776.260.719 - D12.776.660.235.400.750 - D12.776.664.235.400.750 - D12.776.930.823

**Synonyms:** - SOX Family of Transcription Factors - SOX Transcription Factor Family - SRY (Sex Determining Region Y)-Box Proteins