Jumonji Domain-Containing Histone Demethylases

**Definition:** A family of histone demethylases that share a conserved Jumonji C domain. The enzymes function via an iron-dependent dioxygenase mechanism that couples the conversion of 2-oxoglutarate to succinate to the hydroxylation of N-methyl groups.

**Tree numbers:** - D08.811.682.662.582.475.500 - D08.811.682.690.416.388

**Synonyms:** - JmjC Domain-Containing Histone Demethylases