Donohue Syndrome

**Definition:** Rare autosomal recessive syndrome of extreme insulin resistance due to mutations in the binding domain of INSULIN RECEPTOR. Clinical features include severe intrauterine and postnatal growth restriction, characteristic dysmorphic FACIES; HIRSUTISM; VIRILIZATION; multiple endocrine abnormalities, and early death.

**Tree numbers:** - C05.660.207.325 - C16.131.077.313 - C16.320.215 - C18.452.394.750.654 - C19.246.537

**Synonyms:** - Leprechaunism