Unfolded Protein Response

**Definition:** A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.

**Tree numbers:** - G02.111.660.871.790.600.962 - G02.111.691.600.850 - G03.734.871.790.600.850 - G04.434.500 - G05.308.670.600.850