Frontotemporal Lobar Degeneration

**Definition:** Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.

**Tree numbers:** - C10.228.140.380.266 - C10.574.950.300 - C18.452.845.800.300 - F03.615.400.380

**Synonyms:** - FTLD