Telomere Shortening

**Definition:** The loss of some TELOMERE sequence during DNA REPLICATION of the first several base pairs of a linear DNA molecule; or from DNA DAMAGE. Cells have various mechanisms to restore length (TELOMERE HOMEOSTASIS.) Telomere shortening is involved in the progression of CELL AGING.

**Tree numbers:** - G02.111.225.940 - G04.043.630 - G05.226.940 - G07.345.124.130.630