Axin Signaling Complex

**Definition:** A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.

**Tree numbers:** - D05.500.117 - D12.776.476.081

**Synonyms:** - Axin Signaling Complex Proteins - beta-Catenin Destruction Complex