Immunoreceptor Tyrosine-Based Activation Motif

**Definition:** A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.

**Tree numbers:** - G02.111.570.820.709.275.500.440

**Synonyms:** - Immune Receptor Tyrosine-Based Activation Motif - Immuno-Receptor Tyrosine-Based Activation Motif