Immunoreceptor Tyrosine-Based Inhibition Motif

**Definition:** A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins that negatively regulate the signal transduction processes emanating from transmembrane proteins containing IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIFS. The CONSENSUS SEQUENCE of this motif is I(or V)LXYXXL(or V) (where X denotes any amino acid). Also known as ITIM motifs.

**Tree numbers:** - G02.111.570.820.709.275.500.480

**Synonyms:** - Immuno-Receptor Tyrosine-Based Inhibition Motif - Immune Receptor Tyrosine-Based Inhibition Motif