Claudin-5

**Definition:** A claudin subtype that is found localized to TIGHT JUNCTIONS in VASCULAR ENDOTHELIAL CELLS. The protein was initially identified as one of several proteins which are deleted in VELOCARDIOFACIAL SYNDROME and may play an important role in maintaining the integrity of the BLOOD-BRAIN BARRIER.

**Tree numbers:** - D12.776.543.940.200.500

**Synonyms:** - Claudin 5 - Transmembrane Protein Deleted in Velocardiofacial Syndrome - TMVCF Protein