Peroxisomal Bifunctional Enzyme

**Definition:** A monomeric protein found in liver peroxisomes that contains two enzymatically active domains; an enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase domain, and an (S)-3-hydroxyacyl-CoA dehydrogenase domain. The enzyme is stereospecific with regards to how cis and trans double bonds are metabolized. It is complemented by PEROXISOMAL MULTIFUNCTIONAL PROTEIN-2, which has the opposite stereospecificity.

**Tree numbers:** - D08.811.399.475.400.349.500 - D08.811.520.241.300.250.750 - D08.811.641.781 - D08.811.682.047.820.150.207.500

**Synonyms:** - Peroxisomal-Bifunctional Enzymes - L-Bifunctional Enzyme - L-Peroxisomal Bifunctional Enzyme - Peroxisomal Multifunctional beta-Oxidation Protein - Peroxisomal Trifunctional Enzyme - 2-Enoyl-CoA Hydratase, 3-Hydroxyacyl-CoA Dehydrogenase-delta 3, delta 2-Enoyl-CoA Isomerase - Enoyl-CoA Hydratase-3-Hydroxyacyl-CoA Dehydrogenase - Peroxisomal Hydratase-Dehydrogenase-Epimerase