Peroxisomal Multifunctional Protein-2

**Definition:** A dimeric protein found in liver peroxisomes that plays an important role in FATTY ACID metabolism and steroid metabolism. The dimer is formed by cleavage of a single protein precursor and contains an enoyl-CoA hydratase-2 domain and a second domain that displays (S)-3-hydroxyacyl-CoA dehydrogenase and 17-beta-estradiol dehydrogenase activities. The enzyme is stereospecific with regards to arrangement of the substrate double bonds and position of the 3-hydroxy group of the reaction intermediate. It is complemented by PEROXISOMAL BIFUNCTIONAL ENZYME, which has the opposite reaction stereospecificity.

**Tree numbers:** - D08.811.520.241.300.275.500 - D08.811.641.812 - D08.811.682.047.436.375.640 - D08.811.682.047.820.150.926

**Synonyms:** - 17-beta-Hydroxysteroid Dehydrogenase 4 - 3-alpha,7-alpha,12-alpha-Trihydroxy-5-beta-Cholest-24-enoyl-CoA Hydratase - Peroxisomal Multifunctional Enzyme Type 2