Mad2 Proteins

**Definition:** Mad2 is a component of the spindle-assembly checkpoint apparatus. It binds to and inhibits the Cdc20 activator subunit of the anaphase-promoting complex, preventing the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Mad2 is required for proper microtubule capture at KINETOCHORES.

**Tree numbers:** - D12.776.167.313 - D12.776.660.526

**Synonyms:** - Mad2 Mitotic Arrest Deficient-like 1 Proteins