Separase

**Definition:** Separase is a caspase-like cysteine protease, which plays a central role in triggering ANAPHASE by cleaving the SCC1/RAD21 subunit of the cohesin complex. Cohesin holds the sister CHROMATIDS together during METAPHASE and its cleavage results in chromosome segregation.

**Tree numbers:** - D08.811.277.656.262.500.792 - D08.811.277.656.300.200.792 - D12.776.167.552