Securin

**Definition:** Securin is involved in the control of the metaphase-anaphase transition during MITOSIS. It promotes the onset of anaphase by blocking SEPARASE function and preventing proteolysis of cohesin and separation of sister CHROMATIDS. Overexpression of securin is associated with NEOPLASTIC CELL TRANSFORMATION and tumor formation.

**Tree numbers:** - D12.776.167.504

**Synonyms:** - Pituitary Tumor-Transforming Gene Protein - Pituitary Tumor-Transforming Proteins - PTTG Protein