Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels

**Definition:** A subgroup of cyclic nucleotide-regulated ION CHANNELS of the superfamily of pore-loop cation channels that are opened by hyperpolarization rather than depolarization. The ion conducting pore passes SODIUM, CALCIUM, and POTASSIUM cations with a preference for potassium.

**Tree numbers:** - D12.776.157.530.400.368 - D12.776.543.550.450.476 - D12.776.543.585.400.476

**Synonyms:** - Ih Cation Channels - Hyperpolarization Cyclic-Nucleotide Gated Ion Channels - I(h) Channels - Hyperpolarization-Activated Cation Channel - HCN Pacemaker Channels - I(h) Cation Channels