Hypoxia-Inducible Factor-Proline Dioxygenases

**Definition:** Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent enzymes that play an important role in mediating cellular adaptive responses to HYPOXIA.

**Tree numbers:** - D08.811.682.690.416.617.500 - D08.811.682.690.708.694.500

**Synonyms:** - HIF Prolyl-4-Hydroxylase - HIF Prolyl-4-Hydroxylases - Hypoxia-Inducible Factor-Proline Dioxygenase