Porencephaly

**Definition:** Cortical malformations characterized by white matter-lined cleft or cyst associated with ISCHEMIA and hemorrhagic insults. Symptoms include delayed growth and development, HYPOTONIA; SEIZURES; SPASTIC HEMIPLEGIA and MACROCEPHALY; MICROCEPHALY; or HYDROCEPHALUS. Mutations in the genes encoding COLLAGEN TYPE IV are associated with familial types.

**Tree numbers:** - C05.660.207.620.500 - C10.500.507.500.625 - C16.131.621.207.620.500 - C16.131.666.507.500.625