Interferon Gamma-1b

**Semantic type:** Amino Acid, Peptide, or Protein|Pharmacologic Substance

**Definition:** A recombinant form of the endogenous cytokine human interferon (IFN) gamma-1b, with immunomodulating activity. Upon administration, IFN gamma-1b targets, binds to, and activates the cell-surface IFN-gamma receptor, stimulating antibody dependent cellular cytotoxicity (ADCC), activating natural killer (NK) cells, and enhancing the oxidative metabolism of macrophages. IFN-gamma plays important roles in the innate and adaptive immune responses.

**Synonyms:** - Actimmune - IFN-g-1b - IFN-gamma 1b - IFNg-1b - INTERFERON GAMMA-1B - Interferon gamma-1b - Interferon gamma-1b, Recombinant - N(Sup 2)-L-Methionyl-1-139-Interferon G - N(sup 2)-L-Methionyl-1-139-interferon gamma (Human Lymphocyte Protein Moiety Reduced) - Recombinant Interferon Gamma-1b - gamma Interferon 1B