Rintatolimod

**Semantic type:** Nucleic Acid, Nucleoside, or Nucleotide|Pharmacologic Substance

**Definition:** A synthetic derivative of inosinic acid with antiretroviral and immunomodulatory properties. Atvogen acts through a number of pathways to stimulate intracellular antiviral activity of the immune system: it stimulates interferon production; activates the oligoadenylate synthase-RNase L pathway; stimulates natural killer cell activity; and acts as a non-mitogenic stimulator of the immune system. This agent also inhibits replication of human immunodeficiency virus (HIV) in vitro. (NCI04)

**Synonyms:** - Ampligen - Ampligen - Atvogen - Poly(I).Poly(c12,U) - Poly(Inosinic Acid) Poly(Cytidylic(12), Uridylic)Acid - RINTATOLIMOD