Ammonium Trichlorotellurate

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A synthetic non-toxic tellurium derivative, structurally similar to cisplatin, with immunostimulatory and anti-hair loss properties. Ammonium trichlorotellurate induces production of colony stimulating factor (CSF), interleukin-2 (IL-2), and IL-2 receptors by increasing the calcium ion influx through the cell membrane and subsequently exerts its immunostimulatory effects through the CSF-mediated increase in macrophage/granulocytes. This agent is also a potent inducer of interferon and a spectrum of cytokines such as IL-1, IL-6, and tumor necrosis factor (TNF). In animal studies, ammonium trichlorotellurate exerts its anti-hair loss effect by inducing anagen and obstructing spontaneous catagen via promoting follicular keratinocyte proliferation and interfering with terminal differentiation, respectively.

**Synonyms:** - AMMONIUM TRICHLOROTELLURATE - AS-101 - IVX-Q-101 - Ossirene - Tellurate(1-), trichloro[1,2-ethanediolato(2-)-kappa-O,kappa-O']-,ammonium, (SP-5-22)-