RPN1/MECOM Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal rearrangement either t(3;3)(q21;q26) or inv(3)(q21q26) which fuses the promoter sequences from the RPN1 gene on either the 5' or 3' side of the coding sequence of the MECOM gene. This rearrangement is associated with overexpression of the MDS1 and EVI1 complex locus protein EVI1 and 3q21q26 syndrome-related leukemias.

**Synonyms:** - RPN1-EVI1 Fusion Gene - RPN1-MECOM Fusion Gene