Gallium Ga 68-Edotreotide

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate consisting of the octreotide derivative edotreotide labeled with gallium 68 (Ga-68) with potential application in somatostatin receptor (SSTR) imaging in conjunction with positron emission tomography (PET). Similar to octreotide, gallium Ga 68-edotreotide binds to SSTRs, especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells and their metastases, thereby allowing for imaging of SSTR-expressing cells upon PET. Gallium Ga 68-edotreotide is produced by substituting tyrosine for phenylalanine at the 3 position of the somatostatin analogue octreotide (Tyr3-octreotide or TOC) and chelating the substituted octreotide to Ga-68 via the macrocyclic chelating agent dodecanetetraacetic acid (DOTA).

**Synonyms:** - 68Ga-DOTA-TOC - 68Ga-DOTA-d-Phe1-Tyr3-octreotide - EDOTREOTIDE GALLIUM GA-68 - Ga-68 DOTA0-Tyr3-octreotide - Ga-68 DOTATOC - Ga-68-DOTA-TOC - Ga-68-DOTA-Tyr(3)-octreotide - Gallium Ga 68-DOTATOC