GRN wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human GRN wild-type allele is located in the vicinity of 17q21.32 and is approximately 8 kb in length. This allele, which encodes progranulin protein, plays a role in wound healing, lysosome acidification and the modulation of inflammation. Mutation of the gene is associated with primary progressive aphasia, neuronal ceroid lipofuscinosis type 11 and ubiquitin-positive frontotemporal dementia.

**Synonyms:** - CLN11 - GEP - GP88 - Glycoprotein, 88-kD Gene - Granulin Gene - Granulin Precursor wt Allele - Granulin-Epithelin Gene - PCDGF - PEPI - PGRN