FLT3/KIT Kinase Inhibitor AKN-028

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable protein tyrosine kinase inhibitor for FMS-related tyrosine kinase 3 (FLT3; STK1) and stem cell factor receptor (SCFR; KIT), with potential antineoplastic activity. FLT3/KIT kinase inhibitor AKN-028 binds to and inhibits both the wild-type and mutated forms of FLT3 and SCFR. This may result in an inhibition of tumor cell proliferation in cancer cell types that overexpress these receptor tyrosine kinases.

**Synonyms:** - AKN-028 - AKN-028 - BVT-II