Iobenguane I-124

**Semantic type:** Pharmacologic Substance

**Definition:** A radioconjugate composed of the positron-emitting radioisotope iodine I 124 labeled to iobenguane, the synthetic aralkylguanidine analogue of the neurotransmitter norepinephrine (NE), with potential diagnostic imaging applications upon positron emitting tomography (PET) or computed tomography (CT). Upon administration, iobenguane I-124 is taken up and accumulates in the granules of adrenal medullary chromaffin cells and in the pre-synaptic granules of adrenergic neurons in a manner almost identical with that of NE. In turn, tumor cells can be imaged upon PET or CT.

**Synonyms:** - 124I-MIBG - 124I-metaiodobenzylguanidine - IOBENGUANE I-124 - Iodine I 124 Iobenguane - Iodine I 124 Metaiodobenzylguanidine