Bisantrene

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. (NCI04)

**Synonyms:** - 9,10-Anthracenedicarboxakdehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone] - 9,10-Anthracenedicarboxaldehyde Bis(2-imidazolin-2-yl)hydrazone - BISANTRENE