Amoxicillin-Clavulanate Potassium

**Semantic type:** Antibiotic|Organic Chemical|Pharmacologic Substance

**Definition:** A combination of the semisynthetic broad-spectrum antibiotic amoxicillin and the beta-lactamase enzyme inhibitor clavulanate potassium. Clavulanate potassium increases the serum half-life of amoxicillin by inhibiting beta-lactamase-mediated metabolism of amoxicillin. Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin binding proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial cell walls.

**Synonyms:** - Augmentin - Augmentin - amoxicillin-clavulanate potassium