SH2B3 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SH2B3 wild-type allele is located in the vicinity of 12q24 and is approximately 46 kb in length. This allele, which encodes SH2B adapter protein 3, is involved in signal transduction. Mutation of the gene is associated with susceptibility to both celiac disease type 13 and insulin-dependent diabetes mellitus.

**Synonyms:** - IDDM20 - LNK - SH2B Adaptor Protein 3 wt Allele