3-Chlorotyrosine

**Semantic type:** Organic Chemical

**Definition:** A specific biomarker of hypochlorous acid (HClO), the oxidation product of myeloperoxidase (MPO). Under oxidative stress, 3-chlorotyrosine is produced in proteins with tyrosine residues by the strong oxidant HClO. HClO which is formed at sites of inflammation is also the anti-bacterial molecule produced by neutrophils through MPO-catalyzed oxidation. MPO is a heme-containing enzyme secreted by activated neutrophils and monocytes; it is the only enzyme that produces HClO. Therefore, 3-chlorotyrosine can potentially be used to help determine the extent of neutrophilic inflammation.

**Synonyms:** - 3-CHLOROTYROSINE - 3-Chloro-L-Tyrosine - Chlorotyrosine - Cl-Tyr - L-(8CI)-3-Chloro-Tyrosine - Monochlorotyrosine