F12 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human F12 wild-type allele is located within 5q33-qter and is approximately 8 kb in length. This allele, which encodes coagulation factor XII protein, plays a role in coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Mutations in the F12 gene are associated with angioedema, hereditary, type III.

**Synonyms:** - Coagulation Factor XII (Hageman Factor) wt Allele - HAE3 - HAEX - HAF