Darolutamide

**Semantic type:** Pharmacologic Substance

**Definition:** A formulation containing an androgen receptor (AR) antagonist with potential antineoplastic activity. Darolutamide binds to ARs in target tissues; subsequently, inhibiting androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus. This prevents binding to and transcription of AR-responsive genes that regulate prostate cancer cell proliferation. This ultimately leads to an inhibition of growth in AR-expressing prostate cancer cells.

**Synonyms:** - Antiandrogen ODM-201 - BAY 1841788 - BAY-1841788 - BAY1841788 - DAROLUTAMIDE - Nubeqa - ODM 201 - ODM-201 - ODM201