SOST wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SOST wild-type allele is located in the vicinity of 17q11.2 and is approximately 5 kb in length. This allele, which encodes sclerostin protein, is involved in the negative regulation of ossification. Mutation of the gene is associated with bone dysplasias including sclerosteosis type 1, van Buchem disease and craniodiaphyseal dysplasia autosomal dominant.

**Synonyms:** - CDD - Sclerosteosis Gene - Sclerostin wt Allele - UNQ2976/PRO7455/PRO7476 - VBCH