MTRR wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human MTRR wild-type allele is located in the vicinity of 5p15.31 and is approximately 55 kb in length. This allele, which encodes methionine synthase reductase protein, is involved in both B vitamin metabolism and methionine synthesis. Mutation of the gene is associated with both folate-sensitive neural tube defects and methylcobalamin deficiency type E.

**Synonyms:** - 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase wt Allele - MSR - cblE