ZEB1 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human ZEB1 wild-type allele is located in the vicinity of 10p11.2 and is approximately 214 kb in length. This allele, which encodes zinc finger E-box-binding homeobox 1 protein, plays a role in the transcriptional repression of interleukin-2 gene expression. Mutations in this gene are associated with both posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy.

**Synonyms:** - AREB6 - BZP - DELTAEF1 - FECD6 - NIL-2-A - NIL2A - PPCD3 - Posterior Polymorphous Corneal Dystrophy 3 Gene - T-Lymphocyte-Specific Interleukin 2 Inhibitor Gene - TCF-8 - TCF8 - Transcription Factor 8 (Represses Interleukin 2 Expression) Gene - ZEB - ZFHEP - ZFHX1A - Zinc Finger E-Box Binding Homeobox 1 wt Allele