Microtubule-Associated Proteins 1A/1B Light Chain 3-II

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Microtubule-associated proteins 1A/1B light chain 3-II proteins (LC3-II) are products of the autophagy-dependent processing of microtubule-associated proteins 1A/1B light chain 3 family proteins (LC3). During autophagy, LC3 proteins are cleaved by cysteine protease ATG4B to form LC3-I intermediates which are located in the cytoplasm. As autophagy progresses, LC3-I proteins interact with both ubiquitin-like modifier-activating enzyme ATG7 and ubiquitin-like-conjugating enzyme ATG3. These interactions result in further proteolysis and the conjugation of a phospholipid anchor to form the membrane localized LC3-II.

**Synonyms:** - LC3 II - LC3-II - MAP1LC3-II